Effect of Brain CYP2B Inhibition on Brain Nicotine Levels and Nicotine Self-Administration

The CYP2B enzyme is expressed in human and rat brain, and metabolizes many CNS-acting drugs. The gene that encodes human CYP2B6 is highly polymorphic, where the variation in brain enzyme levels could result in altered brain drug levels. CYP2B can metabolize nicotine, the main psychoactive ingredient...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Neuropsychopharmacology
Main Authors: Garcia, Kristine L P, Coen, Kathy, Miksys, Sharon, Lê, Anh Dzung, Tyndale, Rachel F
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839514/
https://ncbi.nlm.nih.gov/pubmed/25652250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.40
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