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BRAIN CYP2B INDUCTION CAN DECREASE NICOTINE LEVELS IN THE BRAIN

Nicotine can be metabolized by the enzyme CYP2B; brain CYP2B is higher in rats and monkeys treated with nicotine, and in human smokers. A 7-day nicotine treatment increased CYP2B expression in rat brain but not liver, and decreased the behavioral response and brain levels (ex vivo) to the CYP2B subs...

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發表在:Addict Biol
Main Authors: Garcia, Kristine L.P., Lê, Anh Dzung, Tyndale, Rachel F.
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124551/
https://ncbi.nlm.nih.gov/pubmed/27230546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/adb.12411
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