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BRAIN CYP2B INDUCTION CAN DECREASE NICOTINE LEVELS IN THE BRAIN
Nicotine can be metabolized by the enzyme CYP2B; brain CYP2B is higher in rats and monkeys treated with nicotine, and in human smokers. A 7-day nicotine treatment increased CYP2B expression in rat brain but not liver, and decreased the behavioral response and brain levels (ex vivo) to the CYP2B subs...
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| Publié dans: | Addict Biol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5124551/ https://ncbi.nlm.nih.gov/pubmed/27230546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/adb.12411 |
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