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Nicotine Increases Codeine Analgesia Through the Induction of Brain CYP2D and Central Activation of Codeine to Morphine
CYP2D metabolically activates codeine to morphine, which is required for codeine analgesia. Permeability across the blood–brain barrier, and active efflux, suggests that initial morphine in the brain after codeine is due to brain CYP2D metabolism. Human CYP2D is higher in the brains, but not in the...
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| I publikationen: | Neuropsychopharmacology |
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| Huvudupphovsmän: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4916647/ https://ncbi.nlm.nih.gov/pubmed/25630571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.32 |
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