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Propranolol is a mechanism‐based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6‐transgenic mice: Effects on activity and drug responses
BACKGROUND AND PURPOSE: Genetics and drug interactions contribute to large interindividual variation in human CYP2D6 activity. Here, we have characterized propranolol inhibition of human and mouse CYP2D using transgenic (TG) mice, which express both mouse CYP2D and human CYP2D6, and wild‐type (WT) m...
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| Udgivet i: | Br J Pharmacol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7012948/ https://ncbi.nlm.nih.gov/pubmed/31648367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14884 |
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