Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons

Guanine-rich DNA sequences can fold into four-stranded G-quadruplex (G4-DNA) structures. G4-DNA regulates replication and transcription, at least in cancer cells. Here, we demonstrate that, in neurons, pharmacologically stabilizing G4-DNA with G4 ligands strongly downregulates the Atg7 gene. Atg7 is...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Moruno-Manchon, Jose F, Lejault, Pauline, Wang, Yaoxuan, McCauley, Brenna, Honarpisheh, Pedram, Morales Scheihing, Diego A, Singh, Shivani, Dang, Weiwei, Kim, Nayun, Urayama, Akihiko, Zhu, Liang, Monchaud, David, McCullough, Louise D, Tsvetkov, Andrey S
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012600/
https://ncbi.nlm.nih.gov/pubmed/32043463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52283
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