Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice

Amyloid plaques in Alzheimer’s disease (AD) are associated with inflammation. Recent studies demonstrated the involvement of the gut in cerebral amyloid-beta (Aβ) pathogenesis; however, the mechanisms are still not well understood. We hypothesize that the gut bears the Aβ burden prior to brain, high...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Honarpisheh, Pedram, Reynolds, Caroline R., Blasco Conesa, Maria P., Moruno Manchon, Jose F., Putluri, Nagireddy, Bhattacharjee, Meenakshi B., Urayama, Akihiko, McCullough, Louise D., Ganesh, Bhanu P.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084806/
https://ncbi.nlm.nih.gov/pubmed/32138161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21051711
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