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Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons
Guanine-rich DNA sequences can fold into four-stranded G-quadruplex (G4-DNA) structures. G4-DNA regulates replication and transcription, at least in cancer cells. Here, we demonstrate that, in neurons, pharmacologically stabilizing G4-DNA with G4 ligands strongly downregulates the Atg7 gene. Atg7 is...
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| 出版年: | eLife |
|---|---|
| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7012600/ https://ncbi.nlm.nih.gov/pubmed/32043463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52283 |
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