Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons

Guanine-rich DNA sequences can fold into four-stranded G-quadruplex (G4-DNA) structures. G4-DNA regulates replication and transcription, at least in cancer cells. Here, we demonstrate that, in neurons, pharmacologically stabilizing G4-DNA with G4 ligands strongly downregulates the Atg7 gene. Atg7 is...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Moruno-Manchon, Jose F, Lejault, Pauline, Wang, Yaoxuan, McCauley, Brenna, Honarpisheh, Pedram, Morales Scheihing, Diego A, Singh, Shivani, Dang, Weiwei, Kim, Nayun, Urayama, Akihiko, Zhu, Liang, Monchaud, David, McCullough, Louise D, Tsvetkov, Andrey S
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012600/
https://ncbi.nlm.nih.gov/pubmed/32043463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52283
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