The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons

The G-quadruplex is a non-canonical DNA secondary structure formed by four DNA strands containing multiple runs of guanines. G-quadruplexes play important roles in DNA recombination, replication, telomere maintenance, and regulation of transcription. Small molecules that stabilize the G-quadruplexes...

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Dettagli Bibliografici
Pubblicato in:Aging (Albany NY)
Autori principali: Moruno-Manchon, Jose F., Koellhoffer, Edward C., Gopakumar, Jayakrishnan, Hambarde, Shashank, Kim, Nayun, McCullough, Louise D., Tsvetkov, Andrey S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636668/
https://ncbi.nlm.nih.gov/pubmed/28904242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101282
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