The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons

The G-quadruplex is a non-canonical DNA secondary structure formed by four DNA strands containing multiple runs of guanines. G-quadruplexes play important roles in DNA recombination, replication, telomere maintenance, and regulation of transcription. Small molecules that stabilize the G-quadruplexes...

Full description

Saved in:
Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Moruno-Manchon, Jose F., Koellhoffer, Edward C., Gopakumar, Jayakrishnan, Hambarde, Shashank, Kim, Nayun, McCullough, Louise D., Tsvetkov, Andrey S.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636668/
https://ncbi.nlm.nih.gov/pubmed/28904242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101282
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items