Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms

Bile acids have been shown to inhibit human (h) carbonic anhydrases (CA, EC 4.2.1.1) along the gastrointestinal tract, including hCA II. The elucidation of the hormonal inhibition mechanism of the bile acid cholate to hCA II was provided in 2014 by X-ray crystallography. Herein, we extend the inhibi...

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Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Nocentini, Alessio, Bonardi, Alessandro, Gratteri, Paola, Cerra, Bruno, Gioiello, Antimo, Supuran, Claudiu T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011995/
https://ncbi.nlm.nih.gov/pubmed/30221552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1512597
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