Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms

Bile acids have been shown to inhibit human (h) carbonic anhydrases (CA, EC 4.2.1.1) along the gastrointestinal tract, including hCA II. The elucidation of the hormonal inhibition mechanism of the bile acid cholate to hCA II was provided in 2014 by X-ray crystallography. Herein, we extend the inhibi...

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Detalles Bibliográficos
Publicado en:J Enzyme Inhib Med Chem
Main Authors: Nocentini, Alessio, Bonardi, Alessandro, Gratteri, Paola, Cerra, Bruno, Gioiello, Antimo, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2018
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011995/
https://ncbi.nlm.nih.gov/pubmed/30221552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1512597
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