Carbonyl Reductase 1 Plays a Significant Role in Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the Majority of the Doxorubicinol-Forming Activity Remains Unidentified

Doxorubicin is a widely used cancer therapeutic, but its effectiveness is limited by cardiotoxic side effects. Evidence suggests cardiotoxicity is due not to doxorubicin, but rather its metabolite, doxorubicinol. Identification of the enzymes responsible for doxorubicinol formation is important in d...

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Vydáno v:Drug Metab Dispos
Hlavní autoři: Breysse, Daniel H., Boone, Ryan M., Long, Cameron M., Merrill, Miranda E., Schaupp, Christopher M., White, Collin C., Kavanagh, Terrance J., Schmidt, Edward E., Merrill, Gary F.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011114/
https://ncbi.nlm.nih.gov/pubmed/31955137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.089326
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