Protective effect of 23‐hydroxybetulinic acid on doxorubicin‐induced cardiotoxicity: a correlation with the inhibition of carbonyl reductase‐mediated metabolism

BACKGROUND AND PURPOSE: The clinical use of doxorubicin, an effective anticancer drug, is severely hampered by its cardiotoxicity. 23‐Hydroxybetulinic acid (23‐HBA), isolated from P ulsatilla chinensis, enhances the anticancer effect of doxorubicin while simultaneously reducing its cardiac toxicity,...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Zhou, Fang, Hao, Gang, Zhang, Jingwei, Zheng, Yuanting, Wu, Xiaolan, Hao, Kun, Niu, Fang, Luo, Dan, Sun, Yuan, Wu, Liang, Ye, Wencai, Wang, Guangji
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2015
Konular:
Themed Section: Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667859/
https://ncbi.nlm.nih.gov/pubmed/25363561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12995
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