Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

Autophagy is essential for cellular survival and energy homeostasis under nutrient deprivation. Despite the emerging importance of nuclear events in autophagy regulation, epigenetic control of autophagy gene transcription remains unclear. Here, we report fasting-induced Fibroblast Growth Factor-21 (...

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Publicado no:Nat Commun
Main Authors: Byun, Sangwon, Seok, Sunmi, Kim, Young-Chae, Zhang, Yang, Yau, Peter, Iwamori, Naoki, Xu, H. Eric, Ma, Jian, Kemper, Byron, Kemper, Jongsook Kim
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010817/
https://ncbi.nlm.nih.gov/pubmed/32042044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14384-z
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