FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of β-Klotho

The bile acid (BA)-sensing nuclear receptor, farnesoid X receptor (FXR), regulates postprandial metabolic responses, including inhibition of BA synthesis, by inducing the intestinal hormone, fibroblast growth factor (FGF)15 (FGF19 in human). In this study, we tested a novel hypothesis that FXR not o...

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Vydáno v:Mol Endocrinol
Hlavní autoři: Fu, Ting, Kim, Young-Chae, Byun, Sangwon, Kim, Dong-Hyun, Seok, Sunmi, Suino-Powell, Kelly, Xu, H. Eric, Kemper, Byron, Kemper, Jongsook Kim
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2016
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695634/
https://ncbi.nlm.nih.gov/pubmed/26505219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1226
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