Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho

MicroRNA-34a (miR-34a) is the most highly elevated hepatic miR in obese mice and is also substantially elevated in patients who have steatosis, but its role in obesity and metabolic dysfunction remains unclear. After a meal, FGF19 is secreted from the ileum; binds to a hepatic membrane receptor comp...

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Detaylı Bibliyografya
Asıl Yazarlar: Fu, Ting, Choi, Sung-E, Kim, Dong-Hyun, Seok, Sunmi, Suino-Powell, Kelly M., Xu, H. Eric, Kemper, Jongsook Kim
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479576/
https://ncbi.nlm.nih.gov/pubmed/22988100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205951109
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