MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function

Brown fat generates heat through uncoupled respiration, protecting against hypothermia and obesity. Adult humans have brown fat, but the amounts and activities are substantially decreased in obesity, by unknown mechanisms. Here we show that elevated microRNA 34a (miR-34a) in obesity inhibits fat bro...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Fu, Ting, Seok, Sunmi, Choi, Sunge, Huang, Zhang, Suino-Powell, Kelly, Xu, H. Eric, Kemper, Byron, Kemper, Jongsook Kim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248715/
https://ncbi.nlm.nih.gov/pubmed/25182532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00596-14
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