Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3

Sirtuin 3 (SIRT3) deacetylates and regulates many mitochondrial proteins to maintain health, but its functions are depressed in aging and obesity. The best-studied sirtuin, SIRT1, counteracts aging- and obesity-related diseases by deacetylating many proteins, but whether SIRT1 has a role in deacetyl...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Kwon, Sanghoon, Seok, Sunmi, Yau, Peter, Li, Xiaoling, Kemper, Byron, Kemper, Jongsook Kim
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655509/
https://ncbi.nlm.nih.gov/pubmed/28808064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.778720
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