SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism

The SIRT1 deacetylase inhibits fat synthesis and stimulates fat oxidation in response to fasting, but the underlying mechanisms remain unclear. Here we report that SREBP-1c, a key lipogenic activator, is an in vivo target of SIRT1. SIRT1 interaction with SREBP-1c was increased during fasting and dec...

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Detalhes bibliográficos
Main Authors: Ponugoti, Bhaskar, Kim, Dong-Hyun, Xiao, Zhen, Smith, Zachary, Miao, Ji, Zang, Mengwei, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Veenstra, Timothy D., Kemper, Jongsook Kim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962496/
https://ncbi.nlm.nih.gov/pubmed/20817729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122978
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