SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism

The SIRT1 deacetylase inhibits fat synthesis and stimulates fat oxidation in response to fasting, but the underlying mechanisms remain unclear. Here we report that SREBP-1c, a key lipogenic activator, is an in vivo target of SIRT1. SIRT1 interaction with SREBP-1c was increased during fasting and dec...

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Hlavní autoři: Ponugoti, Bhaskar, Kim, Dong-Hyun, Xiao, Zhen, Smith, Zachary, Miao, Ji, Zang, Mengwei, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Veenstra, Timothy D., Kemper, Jongsook Kim
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962496/
https://ncbi.nlm.nih.gov/pubmed/20817729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122978
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