FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states

The nuclear bile acid receptor FXR is critical for regulation of lipid and glucose metabolism. Here we report that FXR is a target of SIRT1, a deacetylase that mediates nutritional and hormonal modulation of hepatic metabolism. Lysine 217 of FXR is the major acetylation site targeted by p300 and SIR...

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Detalhes bibliográficos
Main Authors: Kemper, Jongsook Kim, Xiao, Zhen, Ponugoti, Bhaskar, Miao, Ji, Fang, Sungsoon, Kanamaluru, Deepthi, Tsang, Stephanie, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Veenstra, Timothy D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785075/
https://ncbi.nlm.nih.gov/pubmed/19883617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.09.009
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