A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Prot...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:EMBO J
Päätekijät: Kim, Dong-Hyun, Xiao, Zhen, Kwon, Sanghoon, Sun, Xiaoxiao, Ryerson, Daniel, Tkac, David, Ma, Ping, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Zhou, Edward, Xu, H Eric, Palvimo, Jorma J, Chen, Lin-Feng, Kemper, Byron, Kemper, Jongsook Kim
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BlackWell Publishing Ltd 2015
Aiheet:
Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337071/
https://ncbi.nlm.nih.gov/pubmed/25425577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489527
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia