A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Prot...

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Опубликовано в: :EMBO J
Главные авторы: Kim, Dong-Hyun, Xiao, Zhen, Kwon, Sanghoon, Sun, Xiaoxiao, Ryerson, Daniel, Tkac, David, Ma, Ping, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Zhou, Edward, Xu, H Eric, Palvimo, Jorma J, Chen, Lin-Feng, Kemper, Byron, Kemper, Jongsook Kim
Формат: Artigo
Язык:Inglês
Опубликовано: BlackWell Publishing Ltd 2015
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337071/
https://ncbi.nlm.nih.gov/pubmed/25425577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489527
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