BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination

Activation of farnesoid X receptor (FXR) by obeticholic acid (OCA) reduces hepatic inflammation and fibrosis in patients with primary biliary cholangitis (PBC), a life-threatening cholestatic liver failure. Inhibition of bromodomain-containing protein 4 (BRD4) also has antiinflammatory, antifibrotic...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Jung, Hyunkyung, Chen, Jinjing, Hu, Xiangming, Sun, Hao, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Kemper, Byron, Chen, Lin-Feng, Kemper, Jongsook Kim
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821603/
https://ncbi.nlm.nih.gov/pubmed/33290278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.141640
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