Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages

Macrophage-mediated inflammatory response has been implicated in the pathogenesis of obesity and insulin resistance. Brd4 has emerged as a key regulator in the innate immune response. However, the role of Brd4 in obesity-associated inflammation and insulin resistance remains uncharacterized. Here, w...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Hu, Xiangming, Dong, Xingchen, Li, Guo, Chen, Yanheng, Chen, Jinjing, He, Xiaoxin, Sun, Hao, Kim, Dong-Hyun, Kemper, Jongsook Kim, Chen, Lin-Feng
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119191/
https://ncbi.nlm.nih.gov/pubmed/33830083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.143379
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