Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-induced Obesity

De novo lipogenesis in adipocytes, especially with high fat feeding, is poorly understood. We demonstrate that an adipocyte lipogenic pathway encompassing fatty acid synthase (FAS) and PexRAP (Peroxisomal Reductase Activating PPARγ) modulates endogenous PPARγ activation and adiposity. Mice lacking F...

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Hlavní autoři: Lodhi, Irfan J., Yin, Li, Jensen-Urstad, Anne P. L., Funai, Katsuhiko, Coleman, Trey, Baird, John H., El Ramahi, Meral K., Razani, Babak, Song, Haowei, Fu-Hsu, Fong, Turk, John, Semenkovich, Clay F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467338/
https://ncbi.nlm.nih.gov/pubmed/22863804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.06.013
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