Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-induced Obesity

De novo lipogenesis in adipocytes, especially with high fat feeding, is poorly understood. We demonstrate that an adipocyte lipogenic pathway encompassing fatty acid synthase (FAS) and PexRAP (Peroxisomal Reductase Activating PPARγ) modulates endogenous PPARγ activation and adiposity. Mice lacking F...

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Detalhes bibliográficos
Main Authors: Lodhi, Irfan J., Yin, Li, Jensen-Urstad, Anne P. L., Funai, Katsuhiko, Coleman, Trey, Baird, John H., El Ramahi, Meral K., Razani, Babak, Song, Haowei, Fu-Hsu, Fong, Turk, John, Semenkovich, Clay F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467338/
https://ncbi.nlm.nih.gov/pubmed/22863804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.06.013
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