Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-induced Obesity

De novo lipogenesis in adipocytes, especially with high fat feeding, is poorly understood. We demonstrate that an adipocyte lipogenic pathway encompassing fatty acid synthase (FAS) and PexRAP (Peroxisomal Reductase Activating PPARγ) modulates endogenous PPARγ activation and adiposity. Mice lacking F...

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Detaylı Bibliyografya
Asıl Yazarlar: Lodhi, Irfan J., Yin, Li, Jensen-Urstad, Anne P. L., Funai, Katsuhiko, Coleman, Trey, Baird, John H., El Ramahi, Meral K., Razani, Babak, Song, Haowei, Fu-Hsu, Fong, Turk, John, Semenkovich, Clay F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467338/
https://ncbi.nlm.nih.gov/pubmed/22863804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.06.013
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