Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

Bile acids (BAs) are recently recognized signalling molecules that profoundly affect metabolism. Because of detergent-like toxicity, BA levels must be tightly regulated. An orphan nuclear receptor, Small Heterodimer Partner (SHP), plays a key role in this regulation, but how SHP senses the BA signal...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Kim, Dong-Hyun, Kwon, Sanghoon, Byun, Sangwon, Xiao, Zhen, Park, Sean, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Kemper, Byron, Kemper, Jongsook Kim
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947186/
https://ncbi.nlm.nih.gov/pubmed/27412403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12179
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