Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver

Sirtuin1 (SIRT1) deacetylase delays and improves many obesity-related diseases, including nonalcoholic fatty liver disease (NAFLD) and diabetes, and has received great attention as a drug target. SIRT1 function is aberrantly low in obesity, so understanding the underlying mechanisms is important for...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Choi, Sung E., Kwon, Sanghoon, Seok, Sunmi, Xiao, Zhen, Lee, Kwan-Woo, Kang, Yup, Li, Xiaoling, Shinoda, Kosaku, Kajimura, Shingo, Kemper, Byron, Kemper, Jongsook Kim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514454/
https://ncbi.nlm.nih.gov/pubmed/28533219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00006-17
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