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FXR-induced lysine-specific histone demethylase, LSD1, reduces hepatic bile acid levels and protects the liver against bile acid toxicity

Bile acids (BAs) function as endocrine signaling molecules that activate multiple nuclear and membrane receptor signaling pathways to control fed-state metabolism. Since the detergent-like property of BAs causes liver damage at high concentrations, hepatic BA levels must be tightly regulated. BA hom...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Kim, Young-Chae, Fang, Sungsoon, Byun, Sangwon, Seok, Sunmi, Kemper, Byron, Kemper, Jongsook Kim
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480214/
https://ncbi.nlm.nih.gov/pubmed/25545350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27677
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