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PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1
Loss of functional BRCA1 protein leads to defects in DNA double-strand break (DSB) repair by homologous recombination (HR) and renders cells hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors used to treat BRCA1/2-deficient cancers. However, upon chronic treatment of BRCA1-mutant cells...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7010753/ https://ncbi.nlm.nih.gov/pubmed/32041954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14563-y |
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