PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1

Loss of functional BRCA1 protein leads to defects in DNA double-strand break (DSB) repair by homologous recombination (HR) and renders cells hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors used to treat BRCA1/2-deficient cancers. However, upon chronic treatment of BRCA1-mutant cells...

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Vydáno v:Nat Commun
Hlavní autoři: Belotserkovskaya, Rimma, Raga Gil, Elisenda, Lawrence, Nicola, Butler, Richard, Clifford, Gillian, Wilson, Marcus D., Jackson, Stephen P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010753/
https://ncbi.nlm.nih.gov/pubmed/32041954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14563-y
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