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PALB2 is an integral component of the BRCA complex required for homologous recombination repair

Mutations in breast cancer susceptibility gene 1 and 2 (BRCA1 and BRCA2) predispose individuals to breast and ovarian cancer development. We previously reported an in vivo interaction between BRCA1 and BRCA2. However, the biological significance of their association is thus far undefined. Here, we r...

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Hlavní autoři: Sy, Shirley M. H., Huen, Michael S. Y., Chen, Junjie
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678481/
https://ncbi.nlm.nih.gov/pubmed/19369211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811159106
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