A Randomized, Placebo-Controlled, Double-Blind, Dose Escalation, Single Dose and Steady State Pharmacokinetics Study of 9cUAB30 in Healthy Volunteers

9cUAB30 is a synthetic analog of 9-cis retinoic acid with chemoprevention activity in cell lines and animal models. The purpose of this phase I placebo-controlled, double-blinded, dose escalation study of 9cUAB30 was to evaluate its safety, pharmacokinetics, and determine a dose for future phase II...

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Publié dans:Cancer Prev Res (Phila)
Auteurs principaux: Kolesar, Jill M., Andrews, Shannon, Green, Heather, Havighurst, Tom C., Wollmer, Barbara W., DeShong, Katina, Laux, Douglas E, Krontiras, Helen, Muccio, Donald D., Kim, KyungMann, Grubbs, Clinton J., House, Margaret G., Parnes, Howard L., Heckman-Stoddard, Brandy M., Bailey, Howard H.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008944/
https://ncbi.nlm.nih.gov/pubmed/31484659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-19-0310
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