The Novel Retinoid, 9cUAB30, Inhibits Telomerase and Induces Apoptosis in HL60 Cells

Telomerase, a ribonucleoprotein important to neoplastic immortality, is up-regulated in approximately 85% of cancers, including leukemias. In this study, 9cUAB30, a novel retinoic acid, resulted in differentiation of HL60 leukemia cells as indicated by morphologic changes characteristic of granulocy...

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Autori principali: Love, William K, DeAngelis, J Tyson, Berletch, Joel B, Phipps, Sharla MO, Andrews, Lucy G, Brouillette, Wayne J, Muccio, Donald D, Tollefsbol, Trygve O
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press Inc. 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533143/
https://ncbi.nlm.nih.gov/pubmed/18795149
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