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Epigenetic and Genetic Mechanisms Contribute to Telomerase Inhibition by EGCG
The ends of human chromosomes are protected from the degradation associated with cell division by 15-20 kb long segments of hexameric repeats of 5′-TTAGGG-3′ termed telomeres. In normal cells telomeres lose up to 300 bp of DNA per cell division that ultimately leads to senescence; however, most canc...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2435482/ https://ncbi.nlm.nih.gov/pubmed/17570133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.21417 |
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