Recombinant dermatan sulfate is a potent activator of heparin cofactor II-dependent inhibition of thrombin

The glycosaminoglycan dermatan sulfate (DS) is a well-known activator of heparin cofactor II-dependent inactivation of thrombin. In contrast to heparin, dermatan sulfate has never been prepared recombinantly from material of non-animal origin. Here we report on the enzymatic synthesis of structurall...

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Bibliographic Details
Published in:Glycobiology
Main Authors: Tykesson, Emil, Maccarana, Marco, Thorsson, Hanna, Liu, Jian, Malmström, Anders, Ellervik, Ulf, Westergren-Thorsson, Gunilla
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008404/
https://ncbi.nlm.nih.gov/pubmed/30869126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwz019
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