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Motif V regulates energy transduction between the flavivirus NS3 ATPase and RNA-binding cleft
The unwinding of dsRNA intermediates is critical for the replication of flavivirus RNA genomes. This activity is provided by the C-terminal helicase domain of viral nonstructural protein 3 (NS3). As a member of the superfamily 2 (SF2) helicases, NS3 requires the binding and hydrolysis of ATP/NTP to...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7008374/ https://ncbi.nlm.nih.gov/pubmed/31914411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011922 |
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