Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

Flavivirus NS5 protein encodes methyltransferase and RNA-dependent RNA polymerase (RdRp) activities. Structural analysis of flavivirus RdRp domains uncovered two conserved cavities (A and B). Both cavities are located in the thumb subdomains and represent potential targets for development of alloste...

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Detalhes bibliográficos
Main Authors: Zou, Gang, Chen, Yen-Liang, Dong, Hongping, Lim, Chin Chin, Yap, Li Jian, Yau, Yin Hoe, Shochat, Susana Geifman, Lescar, Julien, Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077636/
https://ncbi.nlm.nih.gov/pubmed/21349834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214189
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