Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

Flavivirus NS5 protein encodes methyltransferase and RNA-dependent RNA polymerase (RdRp) activities. Structural analysis of flavivirus RdRp domains uncovered two conserved cavities (A and B). Both cavities are located in the thumb subdomains and represent potential targets for development of alloste...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Zou, Gang, Chen, Yen-Liang, Dong, Hongping, Lim, Chin Chin, Yap, Li Jian, Yau, Yin Hoe, Shochat, Susana Geifman, Lescar, Julien, Shi, Pei-Yong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077636/
https://ncbi.nlm.nih.gov/pubmed/21349834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214189
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker