Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

Together with the NS5 polymerase, the NS3 helicase has a pivotal function in flavivirus RNA replication and constitutes an important drug target. We captured the dengue virus NS3 helicase at several stages along the catalytic pathway including bound to single-stranded (ss) RNA, to an ATP analogue, t...

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Autors principals: Luo, Dahai, Xu, Ting, Watson, Randall P, Scherer-Becker, Daniella, Sampath, Aruna, Jahnke, Wolfgang, Yeong, Sui Sum, Wang, Chern Hoe, Lim, Siew Pheng, Strongin, Alex, Vasudevan, Subhash G, Lescar, Julien
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2599875/
https://ncbi.nlm.nih.gov/pubmed/19008861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.232
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