Structure-Based Mutational Analysis of the NS3 Helicase from Dengue Virus

We performed a mutational analysis of the NS3 helicase of dengue virus to test insights gleaned from its crystal structure and identified four residues in the full-length protein that severely impaired either its RTPase and ATPase (Arg-457-458, Arg-460, Arg-463) or helicase (Ile-365, Arg-376) activi...

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Bibliographic Details
Main Authors: Sampath, Aruna, Xu, Ting, Chao, Alex, Luo, Dahai, Lescar, Julien, Vasudevan, Subhash G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1488930/
https://ncbi.nlm.nih.gov/pubmed/16775356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02215-05
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