Flexibility between the Protease and Helicase Domains of the Dengue Virus NS3 Protein Conferred by the Linker Region and Its Functional Implications

The dengue virus (DENV) NS3 protein is essential for viral polyprotein processing and RNA replication. It contains an N-terminal serine protease region (residues 1–168) joined to an RNA helicase (residues 180–618) by an 11-amino acid linker (169–179). The structure at 3.15 Å of the soluble NS3 prote...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Luo, Dahai, Wei, Na, Doan, Danny N., Paradkar, Prasad N., Chong, Yuwen, Davidson, Andrew D., Kotaka, Masayo, Lescar, Julien, Vasudevan, Subhash G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Molecular Biophysics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881804/
https://ncbi.nlm.nih.gov/pubmed/20375022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090936
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