Flexibility between the Protease and Helicase Domains of the Dengue Virus NS3 Protein Conferred by the Linker Region and Its Functional Implications

The dengue virus (DENV) NS3 protein is essential for viral polyprotein processing and RNA replication. It contains an N-terminal serine protease region (residues 1–168) joined to an RNA helicase (residues 180–618) by an 11-amino acid linker (169–179). The structure at 3.15 Å of the soluble NS3 prote...

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Detalhes bibliográficos
Main Authors: Luo, Dahai, Wei, Na, Doan, Danny N., Paradkar, Prasad N., Chong, Yuwen, Davidson, Andrew D., Kotaka, Masayo, Lescar, Julien, Vasudevan, Subhash G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881804/
https://ncbi.nlm.nih.gov/pubmed/20375022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090936
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