NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication

The protein–RNA interactions within the flavivirus replication complex (RC) are not fully understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase bound to the conserved 5′ genomic RNA 5′-AGUUGUUAGUCU-3′ reveals that D290 and R538 make specific interactions with G2 an...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Swarbrick, Crystall M. D., Basavannacharya, Chandrakala, Chan, Kitti W. K., Chan, Shu-Ann, Singh, Daljit, Wei, Na, Phoo, Wint Wint, Luo, Dahai, Lescar, Julien, Vasudevan, Subhash G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Molecular Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728396/
https://ncbi.nlm.nih.gov/pubmed/29165589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1127
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