NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication

The protein–RNA interactions within the flavivirus replication complex (RC) are not fully understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase bound to the conserved 5′ genomic RNA 5′-AGUUGUUAGUCU-3′ reveals that D290 and R538 make specific interactions with G2 an...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Swarbrick, Crystall M. D., Basavannacharya, Chandrakala, Chan, Kitti W. K., Chan, Shu-Ann, Singh, Daljit, Wei, Na, Phoo, Wint Wint, Luo, Dahai, Lescar, Julien, Vasudevan, Subhash G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728396/
https://ncbi.nlm.nih.gov/pubmed/29165589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1127
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