NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication

The protein–RNA interactions within the flavivirus replication complex (RC) are not fully understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase bound to the conserved 5′ genomic RNA 5′-AGUUGUUAGUCU-3′ reveals that D290 and R538 make specific interactions with G2 an...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Swarbrick, Crystall M. D., Basavannacharya, Chandrakala, Chan, Kitti W. K., Chan, Shu-Ann, Singh, Daljit, Wei, Na, Phoo, Wint Wint, Luo, Dahai, Lescar, Julien, Vasudevan, Subhash G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Molecular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728396/
https://ncbi.nlm.nih.gov/pubmed/29165589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1127
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