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Analysis of Flavivirus NS5 Methyltransferase Cap Binding

The flavivirus NS5 N-terminal RNA methyltransferase (MTase) enzyme is responsible for methylating the viral RNA cap structure. To increase our understanding of the mechanism of viral RNA cap binding we performed a detailed structural and biochemical characterization of guanosine cap binding pocket o...

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Detalhes bibliográficos
Main Authors: Geiss, Brian J., Thompson, Aaron A., Andrews, Andrew J., Sons, Robert L., Gari, Hamid H., Keenan, Susan M., Peersen, Olve B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680092/
https://ncbi.nlm.nih.gov/pubmed/19101564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.11.058
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