Allostery in the dengue virus NS3 helicase: Insights into the NTPase cycle from molecular simulations

The C-terminus domain of non-structural 3 (NS3) protein of the Flaviviridae viruses (e.g. HCV, dengue, West Nile, Zika) is a nucleotide triphosphatase (NTPase) -dependent superfamily 2 (SF2) helicase that unwinds double-stranded RNA while translocating along the nucleic polymer. Due to these functio...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Davidson, Russell B., Hendrix, Josie, Geiss, Brian J., McCullagh, Martin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919694/
https://ncbi.nlm.nih.gov/pubmed/29659571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006103
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