Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

Diffuse gastric cancer (DGC) is a lethal malignancy lacking effective systemic therapy. Among the most provocative recent results in DGC has been that of highly recurrent missense mutations in the GTPase RHOA. The function of these mutations has remained unresolved. We demonstrate that RHOA(Y42C), t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Zhang, Haisheng, Schaefer, Antje, Wang, Yichen, Hodge, Richard G., Blake, Devon R., Diehl, J. Nathaniel, Papageorge, Alex G., Stachler, Matthew, Liao, Jennifer, Zhou, Jin, Wu, Zhong, Akarca, Fahire, de Klerk, Leonie K., Derks, Sarah, Pierobon, Mariaelena, Hoadley, Katherine A., Wang, Timothy C., Church, George, Wong, Kwok-Kin, Petricoin, Emanuel F., Cox, Adrienne D., Lowy, Douglas R., Der, Channing J., Bass, Adam J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007383/
https://ncbi.nlm.nih.gov/pubmed/31771969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0811
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados