Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

Diffuse gastric cancer (DGC) is a lethal malignancy lacking effective systemic therapy. Among the most provocative recent results in DGC has been that of highly recurrent missense mutations in the GTPase RHOA. The function of these mutations has remained unresolved. We demonstrate that RHOA(Y42C), t...

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Bibliografske podrobnosti
izdano v:Cancer Discov
Main Authors: Zhang, Haisheng, Schaefer, Antje, Wang, Yichen, Hodge, Richard G., Blake, Devon R., Diehl, J. Nathaniel, Papageorge, Alex G., Stachler, Matthew, Liao, Jennifer, Zhou, Jin, Wu, Zhong, Akarca, Fahire, de Klerk, Leonie K., Derks, Sarah, Pierobon, Mariaelena, Hoadley, Katherine A., Wang, Timothy C., Church, George, Wong, Kwok-Kin, Petricoin, Emanuel F., Cox, Adrienne D., Lowy, Douglas R., Der, Channing J., Bass, Adam J.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007383/
https://ncbi.nlm.nih.gov/pubmed/31771969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0811
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