Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1

We report several receptor tyrosine kinase (RTK) ligands increase RhoA–guanosine triphosphate (GTP) in untransformed and transformed cell lines and determine this phenomenon depends on the RTKs activating the AKT serine/threonine kinase. The increased RhoA-GTP results from AKT phosphorylating three...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Tripathi, Brajendra K., Grant, Tiera, Qian, Xiaolan, Zhou, Ming, Mertins, Philipp, Wang, Dunrui, Papageorge, Alex G., Tarasov, Sergey G., Hunter, Kent W., Carr, Steven A., Lowy, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716279/
https://ncbi.nlm.nih.gov/pubmed/29114068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201703105
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