Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1

We report several receptor tyrosine kinase (RTK) ligands increase RhoA–guanosine triphosphate (GTP) in untransformed and transformed cell lines and determine this phenomenon depends on the RTKs activating the AKT serine/threonine kinase. The increased RhoA-GTP results from AKT phosphorylating three...

詳細記述

保存先:
書誌詳細
出版年:J Cell Biol
主要な著者: Tripathi, Brajendra K., Grant, Tiera, Qian, Xiaolan, Zhou, Ming, Mertins, Philipp, Wang, Dunrui, Papageorge, Alex G., Tarasov, Sergey G., Hunter, Kent W., Carr, Steven A., Lowy, Douglas R.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2017
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716279/
https://ncbi.nlm.nih.gov/pubmed/29114068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201703105
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