Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds

[Image: see text] A series of compounds (including CCG-1423 and CCG-203971) discovered through an MRTF/SRF-dependent luciferase screen has shown remarkable efficacy in a variety of in vitro and in vivo models, including significant reduction of melanoma metastasis and bleomycin-induced fibrosis. Alt...

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Publicat a:ACS Pharmacol Transl Sci
Autors principals: Lisabeth, Erika M., Kahl, Dylan, Gopallawa, Indiwari, Haynes, Sarah E., Misek, Sean A., Campbell, Phillip L., Dexheimer, Thomas S., Khanna, Dinesh, Fox, David A., Jin, Xiangshu, Martin, Brent R., Larsen, Scott D., Neubig, Richard R.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7006939/
https://ncbi.nlm.nih.gov/pubmed/32039344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.8b00048
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